Therapeutic potential of dental follicle-derived stem cells and gold nanoparticles on osteoarthritic temporomandibular joint in guinea pigs (randomized prospective study)

Title (English)

Therapeutic potential of dental follicle-derived stem cells and gold nanoparticles on osteoarthritic temporomandibular joint in guinea pigs (randomized prospective study)

Thong tin bai bao / Article info

• Tac gia / Authors: Amira M. Elsherbini, Samah Khaled Ezzat
• Tap chi / Journal: BMC Oral Health
• Ngay xuat ban / Published: 2026-08-15
• DOI: 10.1186/s12903-026-09529-3
• Nguon / Source: OpenAlex

Abstract (English)

Abstract Background Osteoarthritis (OA) is a complicated autoimmune disease that often causes invasive inflammatory infiltration and serious articular destruction. The global prevalence of temporomandibular disorders (TMDs) is estimated to be around 30% of the population. Several clinical drugs have been reported to have adverse effects ranging from increased inflammation to liver cirrhosis. Even with the introduction of gene therapy, there is still a growing need for therapeutic alternatives for OA. This study aimed to evaluate the effect of dental follicle-derived stem cells (DFSCs) versus gold nanoparticles (AuNPs), on temporomandibular joint (TMJ) osteoarthritis induced by Complete Freund’s Adjuvant (CFA). Methods In this study, for osteoarthritis induction , twice intra-articular injections of complete Freund’s adjuvant (CFA) were performed, once at the beginning of the experiment and again after two weeks. After 4 weeks, the osteoarthritis animals were randomly allocated into three equal groups: osteoarthritis group, osteoarthritis group treated with Nanogold (AuNPs), and osteoarthritis group treated with Dental follicle stem cells (DFSCs). After one month, the TMJs were fixed and processed for staining with hematoxylin and eosin, and the disc thickness was assessed; results were statistically evaluated. Results The osteoarthritis group showed erosion of cartilage and subchondral bone and a thickened disc. Both DFSCs and AuNPs reduced the inflammatory signs. Though statistically non-significant, DFSCs showed a greater reduction in disc thickness. Conclusion This study’s results highlighted the potential use of DFSCs and AuNPs as a promising treatment in TMJ osteoarthritis.

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Bai dang tu dong boi plugin Ortho OA Fetcher. Anh (neu co) tu PubMed Central. Noi dung lay tu nguon open access va dich tu dong – chi mang tinh tham khao.