Enhanced odontoblast regeneration and anti-inflammatory effects of nanocurcumin-loaded BM-MSC-derived exosomes in an LPS-induced periodontitis rat model

Title (English)

Enhanced odontoblast regeneration and anti-inflammatory effects of nanocurcumin-loaded BM-MSC-derived exosomes in an LPS-induced periodontitis rat model

Thong tin bai bao / Article info

• Tac gia / Authors: Nehad M. Abd-elmonsif, Ahmed Morsy, Mona El Deeb
• Tap chi / Journal: BMC Oral Health
• Ngay xuat ban / Published: 2026-09-03
• DOI: 10.1186/s12903-026-09697-2
• Nguon / Source: OpenAlex

Abstract (English)

Abstract Background Periodontitis is commonly known as a chronic inflammatory disease which adversely affects pulpal and periodontal tissues, including odontoblasts. Bone marrow mesenchymal stem cell-derived exosomes (BM-MSC-Exo) and nanocurcumin (NCUR) possess anti-inflammatory and regenerative properties; however, their combined effects on odontoblasts remain insufficiently explored. The research target was to assess the histological, histochemical, and anti-inflammatory effects of BM-MSC-Exo and NCUR-loaded BM-MSC-Exo on odontoblasts of LPS-induced periodontitis in rats. Methods Twenty-eight male albino rats were assigned at random into four groups ( n = 7 each): control, periodontitis, periodontitis treated with BM-MSC-Exo, and periodontitis treated with NCUR-loaded BM-MSC-Exo. Periodontitis was induced via intra-periodontal LPS injections. Histological evaluation was performed using hematoxylin and eosin staining, and collagen synthesis was analyzed using Masson’s trichrome stain. Morphometric analysis of newly formed collagen and enzyme-linked immunosorbent assay (ELISA) of interleukin-10 (IL-10) levels were conducted. Results Untreated periodontitis caused marked odontoblastic degeneration, reduced predentin thickness, and decreased collagen formation. Treatment with BM-MSC-Exo significantly improved odontoblastic architecture, enhanced collagen deposition, and increased IL-10 expression. NCUR-loaded BM-MSC-Exo demonstrated superior regenerative and anti-inflammatory effects, characterized by improved odontoblastic organization, increasing the area of newly formed collagen, and significantly elevated IL-10 levels compared with all other groups ( p < 0.001). Conclusions BM-MSC-Exo exerts regenerative effects on odontoblasts in periodontitis, which are further enhanced by NCUR loading. NCUR-loaded BM-MSC-Exo declares an encouraging cell-free medicinal strategy for regeneration of periodontal and pulpal tissues.

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Bai dang tu dong boi plugin Ortho OA Fetcher. Anh (neu co) tu PubMed Central. Noi dung lay tu nguon open access va dich tu dong – chi mang tinh tham khao.